To investigate the correlation of substance P in middle ear effusion and clinical presentation in secretory otitis media.
Observation on relation between clinical presentation (the course of disease, the hearing loss, quantity of middle ear effusion or quality) and substance P (SP) content of middle ear effusion (MEE) in 64 cases (79 ears) of secretory otitis media (SOM).
SP concentration of MEE in serous group was remarkably higher than that in the mucous group (P < 0.01). SP concentration of MEE had positive correlation with the volume (r = 0.985, P < 0.01), and negative correlation with the course of disease (r = -0.6217, P < 0.01). The hearing loss of mucous group was remarkably higher than that of the serous group (P < 0.01). SP concentration of MEE in serous group had positive correlation with auditory threshold (r = 0.9553, P < 0.01). SP concentration of MEE in mucous had no correlation with auditory threshold.
SP might play an important role in SOM. The detection of SP content in MEE is of important significance for judging quality of MEE and understanding the course of disease.
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